Safety and Reactogenicity of 2 Doses of SARS-CoV-2 Vaccination in Solid Organ Transplant Recipients
نویسندگان
چکیده
Background. We studied the safety and reactogenicity SARS-CoV-2 mRNA vaccines in transplant recipients because immunosuppressed patients were excluded from vaccine trials. Methods. US recruited into this prospective cohort study through social media; those who completed full series between December 9, 2020 March 1, 2021 included. collected demographics, medical history, information within 7 d after doses 1 2 (D1, D2). Associations characteristics reactions evaluated using modified Poisson regression. Results. 741 underwent BNT162b2 (54%) or mRNA-1273 (46%) vaccination. Median (interquartile range) age was 60 (44–69) y, 57% female, 10% non-White. Although local site decreased D2 (85% D1 versus 78% D2, P < 0.001), systemic increased (49% 69% 0.001). Younger participants more likely to develop symptoms (adjusted incidence rate ratio [aIRR] per 10 y = 0.850.900.94, 0.001) (aIRR 0.910.930.96, Participants experienced pain 1.111.662.47, 0.01) redness 1.833.928.41, an antibody response of vaccines. No anaphylaxis, neurologic diagnoses, diagnoses reported. Infections minimal (3% D1, <0.01% One patient reported incident acute rejection post-D2. Conclusions. In solid organ undergoing vaccination, similar that original Severe rare. These early data may help address hesitancy recipients.
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ژورنال
عنوان ژورنال: Transplantation
سال: 2021
ISSN: ['0041-1337', '1534-6080']
DOI: https://doi.org/10.1097/tp.0000000000003780